Posted by Rexly Penaflorida II on Wednesday, September 28, 2011 ? Leave a Comment?
There Can Only Be?One!
Adding to the excite?ment of the Bat?tle?field 3 mul?ti?player beta that began on Sep?tem?ber 27, DICE announced one more item regard?ing the mul?ti?player, and it is?big:
Start?ing in early 2012, the Bat?tle?field World?wide Con?quest Tour?na?ment will begin. Play?ers will need to form teams and par?tic?i?pate in numer?ous events to win the grand prize: $1.6 mil?lion. Together with Vir?gin Gam?ing, DICE is about to put on what just might be the most epic tour?na?ment ever and with a grand prize this huge, it is hard to refuse.
There is one lit?tle catch, how?ever. The tour?na?ment is only avail?able to PS3 and Xbox 360 play?ers. Sorry, PC fans. So if there are those out there who are pur?chas?ing Bat?tle?field 3 next month for the PC, con?sider get?ting a copy for one of the two con?soles. Many will enter, only one team will win. For more infor?ma?tion on the tour?na?ment, check out Vir?gin Gaming?s page on the?event.
[Source:VG247]?
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Share Your Thoughts: Will you par?tic?i?pate in the Bat?tle?field World?wide Con?quest Tour?na?ment? For those with a PC, does this bit of news change your mind about using a con?sole for the?game?
This video that talks about self help and life coaching will help you learn to improve yourself. This is a coaching video coming from one of the best selling inspirational and life coaching movie, \?The secret\?. If you wonder how did the people from that movie achieved what they have, this video has the answer.
Pakistan's former president Musharraf says the US, which has accused Pakistan of complicity in terrorist attacks in Afghanistan, must understand Pakistan's national interests.
Good Reads highlights the best reporting and analysis available on the top international stories of the day ? and other key topics you shouldn't miss.
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There's something about launching a frontal assault on a US embassy and then having a shootout inside a CIA station that captures the attention of US policymakers and news media.
The US blames a Pakistan-based group called the Haqqani network for the US embassy attack in Kabul on Sept. 13, and for more broadly cooperating with the Taliban in their long guerrilla war against the Afghan government. Now, Washington has been considering a number of strong actions against the Haqqani network and its perceived sponsors, the Pakistani military. One US senator even hinted at military action.
But in London, former Pakistani President Gen. Pervez Musharraf told the Telegraph's Duncan Gardham that the US needs to keep working with Pakistan to find a solution to their common problem, the instability of Afghanistan. And, he told the Telegraph, Washington needs to understand that Pakistan has a right to defend its own national interests in a region dominated by Pakistan's existential rival, India.
Responding to a specific question on why Pakistan might be working with the Haqqani network, Mr. Musharraf replied: ?If I was in government I would certainly be thinking how best to defend Pakistan?s interests."
?The United States must understand Pakistan has its own national interest. The United States must accept the compulsions of Pakistan and give assurances."
He added: ?When the coalition talk of leaving in 2014, Pakistan has to really think, what will be the environment and fend for itself against all the exterior pressures, all the exterior manoeuvrings and political manoeuvrings against Pakistan.?
So that's it, then. Pakistan's interests and America's interests are at odds, and it's up to diplomats in Washington and Islamabad to come up with some compromise that makes everyone, if not happy, then at least a little less aggressively homicidal. Which means that the seemingly decision of whether to label the group behind the US embassy attack a "terrorist organization" is not as simple as it sounds.
The Monitor's Howard LaFranchi writes from Washington that putting the Haqqani network on the US State Department's terror watch list could scupper any lingering chance of peace talks with the Taliban ? already stalled after the Taliban killed the Afghan government's chief negotiator ? and could further worsen relations with Pakistan.
BEIRUT?? Once-peaceful Syrian protesters are increasingly taking up arms to fight a six-month military crackdown, frustrated that President Bashar Assad remains in control while more than 2,700 demonstrators are dead, analysts and witnesses say.
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The growing signs of armed resistance may accelerate the cycle of violence gripping the country by giving the government a pretext to use even greater firepower against its opponents. Authorities have already used tanks, snipers and mafia-like gunmen known as "shabiha" who operate as hired guns for the regime.
"If peaceful activism on the part of the protesters turns into violent insurgency, the risk of civil war will dramatically increase and the regime will benefit and likely go for the kill," Bilal Saab, a Middle East expert at the Monterey Institute of International Studies in California, told The Associated Press.
The degree to which Syrian protesters are arming themselves is difficult to quantify because Syria has blocked nearly all outside witnesses to the bloodshed by banning foreign media and restricting local coverage. The state media echoes the party line, which states the regime is fighting thugs and religious extremists who are acting out a foreign conspiracy.
But interviews with a wide group of witnesses, activists and analysts suggest the conflict is becoming more violent. Led by defecting army conscripts and Syrians with access to weapons smuggled in through neighboring Iraq, Turkey and Lebanon, protesters have begun taking up arms to fight back, observers say.
They are being aided by Sunni fighters returning from Iraq to their native Syria.
"Now these Syrian insurgents are returning to their country to help topple the Assad regime," said Qassim al-Araji, a Shiite member of the Iraqi parliament's defense and security committee. "We are happy to see these fighters leaving Iraq, saving us from their evils, but at the same time we do not want major disturbances in neighboring Syria."
A widespread armed revolt would be a potentially dire change in the protest movement, which for strategic reasons has remained mostly peaceful with an eye toward gaining a moral advantage over Assad. In many ways, the movement was modeled after the nonviolent revolutions in Tunisia and Egypt.
But with the U.N. estimating more than 2,700 civilian deaths since the uprising began in mid-March, many protesters are starting to see the limits of a peaceful movement, particularly when compared to the armed uprising in Libya that drove Moammar Gadhafi from power ? albeit with NATO air support.
Although the mass demonstrations in Syria have shaken one of the most authoritarian regimes in the Middle East, the opposition has made no major gains in recent months, it holds no territory and still has no clear leadership.
"The regime is killing the people and some residents are thinking that peaceful demonstrations will take them nowhere, even in 10 years from now," said a prominent Syrian activist who asked that his name and location not be published because of the sensitivity of the issue. "Gunmen and army defectors are fighting side by side against regime forces."
He and other activists said the armed resistance is strongest on the outskirts of Homs, a central city that has seen some of the largest demonstrations, along with Jabal al-Zawiya in Idlib province near the Turkish border.
There also have been increasing reports of attacks on security forces and police patrols. Mohammed Saleh, an opposition figure in Homs, said he saw a police car riddled with bullets and a burned-out security bus in the city last week.
Saleh also said gunmen attacked an army force last week, destroying six armored personnel carriers in Homs.
Another Homs activist, Majd Saleh, confirmed clashes between Syrian troops and army defectors.
"The opposition to the government is gradually transforming into more of an armed resistance," said Vali Nasr, a Middle East expert and former Obama administration official in the State Department. "The brutality of the regime has become enormous and there is increasing pressure on people to defend their families and their villages. They clearly have won a moral argument against the government, but physically it doesn't protect them."
There is no central call to arms by the opposition, in part because there is no clear leadership in the movement. The Syrian opposition is disparate and fragmented, with various parties vying for power as they see an end to more than 40 years of iron rule by Assad and his late father, Hafez.
Still, recent weeks have seen a subtle change in tone. Some Syrians are now calling on protesters to take up arms and inviting foreign military action, hoisting signs that say "Where is NATO?" and urging the world to come to Syria's aid.
The most prominent protest organizers responded swiftly, insisting the movement is entirely peaceful and stressing that the Assad regime will use any violence to justify its ferocious crackdown.
"While we understand the motivation to take up arms or call for military intervention, we specifically reject this position," said a statement last month by the Local Coordination Committees, an activist group with a wide network of sources on the ground across Syria.
"Militarization would ... erode the moral superiority that has characterized the revolution since its beginning," the statement said.
Many activists were hesitant to speak on the record about the armed resistance; others denied it outright. Mohammed Saleh, one of the activists in Homs, blamed the increased violence on drug dealers and smugglers.
But the calls to arms appear to be borne of frustration that the revolt has descended into a stalemate, with neither side willing to give in. The protests have continued nearly every day, but the gatherings have lost some momentum in recent weeks.
U.S. State Department spokesman Mark Toner said the Obama administration understands that frustration, urging the Assad regime to avoid more violence by allowing a peaceful political transition process.
"The great majority of the opposition members have shown extraordinary restraint in the face of the regime's brutality and are demanding their rights through peaceful, unarmed demonstrations," Toner said Monday. "The longer the regime continues to use repression, killing and jailing peaceful marchers and activists both, the more likely that the peaceful protest movement will become more violent."
The U.N. human rights office says the regime has started retaliating against protesters' families to snuff out the uprising, a fearsome new tactic which could be having a chilling effect on the revolution.
"Prominent human rights defenders, inside and outside the country, are reported to have been targeted," U.N. human rights office spokeswoman Ravina Shamdasani said in Geneva on Friday. "We are also concerned by reports of the targeting and attacking of families and sympathizers of the protesters by security forces."
There is little sign of the violence ending anytime soon. International intervention, like the NATO action that helped topple Gadhafi, is all but out of the question. Washington and its allies have shown little appetite for intervening in yet another Arab nation in turmoil.
International sanctions, some of which target Assad personally, have failed to persuade him to ease his crackdown. There had been hopes, since dashed, that European Union sanctions would prove a humiliating personal blow to Assad, a 46-year-old eye doctor who trained in Britain.
There also is real concern that Assad's ouster would spread chaos around the region.
Syria is a geographical and political keystone in the heart of the Middle East, bordering five countries with which it shares religious and ethnic minorities and, in Israel's case, a fragile truce. Its web of allegiances extends to Lebanon's powerful Hezbollah movement and Iran's Shiite theocracy.
A destabilized Syria, the argument goes, could send unsettling ripples through the region.
Syria also has a volatile sectarian divide, making civil unrest one of the most dire scenarios. The Assad regime is dominated by the Alawite minority, an offshoot of Shiite Islam, but the country is overwhelmingly Sunni Muslim.
Alawite dominance has bred resentments, which Assad has worked to tamp down by pushing a strictly secular identity. But he now appears to be relying heavily on his Alawite power base, beginning with highly placed relatives, to crush the resistance.
For many Syrians, the uncertainty over the future is cause for alarm in a country where sectarian warfare is a real, terrifying possibility. Syria is a fragile jigsaw puzzle of Middle Eastern backgrounds including Sunnis, Shiites, Alawites, Christians, Kurds, Druse, Circassians, Armenians and more.
Even for Syrians who despise Assad, the worst-case scenario is a descent into a Lebanese-style civil war ? and Assad has exploited those fears by portraying himself as the only power who can keep the peace. But as faith in the regime erodes, Syrians could decide that protecting themselves will be their only option, regardless of the outcome of the uprising.
"The argument for arming yourself is very strong, whether you think Assad is going to survive or fall," Nasr said. "People are becoming increasingly unconvinced a peaceful transition is in the cards. So either the regime will survive with enormous brutality or it will fall to chaos and violence. Either way, people are taking to arms."
___
AP writers Bassem Mroue in Beirut, Matthew Lee in Washington and Sameer N. Yacoub in Baghdad contributed to this report.
Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
?The Playboy Club? star Eddie Cibrian has an issue with the criticism of his wife, LeAnn Rimes, and her figure.
?It bothers me because, obviously, I know she?s healthy. She eats more than I do sometimes,? Eddie told Billy Bush and Kit Hoover on Monday?s "Access Hollywood Live." ?She?s just a very [conscientious] eater, as far as what she eats. She eats pretty healthy, but she works out pretty hard too and she actually takes pride in the way she looks and it?s a shame that people will jump on the bandwagon just because she is fit. And she?s far from unhealthy.?
VIEW THE PHOTOS: Scenes & Stars Of NBC?s ?The Playboy Club?
Eddie said his country superstar wife compliments her eating routine with a lot of physical activity.
?She works out like crazy. She works out hard. She boxes. She trains,? he said.
VIEW THE PHOTOS: Shows & Stars of Fall Television 2011
The actor said some of the photos that have surfaced of his wife, have been the odd photo of the bunch ? the one that shows her looking slimmer than the rest.
?Whenever you get a picture taken of you, there?s always an angle that looks unflattering for anybody and it?s unfair to use those pictures as the basis of the way that you actually really look,? he said. ?She?s in fantastic shape and very healthy and I love the way she looks.?
Conversely, LeAnn loves the way Eddie looks in his turn as Nick, on NBC?s Monday night drama, ?The Playboy Club.?
VIEW THE PHOTOS: Country Star LeAnn Rimes
?My wife enjoys the show a lot,? he said. ?She comes down to the set quite often.?
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Eddie too seems to enjoy putting on lawyer Nick?s sharp suits.
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?When we come on to the set, we get transformed into this world that we?re trying to bring to America, to kind of give a glimpse of what it was inside this Playboy Club. So it?s fun,? he said.
?The Playboy Club? airs on Mondays at 10 p.m. ET/PT on NBC.
Copyright 2011 by NBC. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
On Monday, Angelina Jolie and part of her brood went to Gwen Stefani's London home for a playdate. Shiloh, 5, Zahara, 6, and 3-year-old twins Vivienne and Knox were all smiles alongside Kingston Rossdale, 5.
PHOTOS: Kingston's super cute style
So how exactly do Jolie, 36, and Stefani, 41, know each other? A source tells Us Weekly that Brad Pitt has been pals with the No Doubt singer and hubby Gavin Rossdale for years. He and ex-wife Jennifer Aniston attended the couple's L.A. wedding in Sept. 2002. "They've run in the same social circle [for a long time]," adds a source.
PHOTOS: Shiloh's adorable fashion choices
When Shiloh and Kingston were born a day apart, the parents became "even better friends. "Right away they started getting [the kids] together for play dates," a source tells Us. "Brad had [the Stefani-Rossdales] up to his Santa Barbara house for the weekend."
PHOTOS: More pics of Vivienne and Knox
Jolie and Pitt, 47, also welcomed Vivienne and Knox in Aug. 2008, just one month before Stefani and Rossdale, 45, had their son Zuma.
PHOTOS: Zuma's precious looks
"All of the kids are very close in age. They've attended each others birthday parties and gotten together several times at each others homes," says a source.
Over the summer, Stefani and Rossdale attended the premier of Pitt's film Tree of Life at Cannes, and now that both families are in London, a source says "it made perfect sense for all of the kids to get together for a playdate!"
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Greek Finance Minister says there have been no discussions with IMF and European Central Bank about scenario of orderly default - @Reuters - breakingnews.com
Story metadata:
New-home sales dipped 2.3 pct. in August to a six-month low, fourth straight month of declines - @AP
[unable to retrieve full-text content]Reputation Risk is one of the most commonly overlooked business risk by startups. Reputation management is key to your business and its long term success. Your business and personal reputation should and must be ...
There are numerous examples of family trees, the history of your family can be customized online. The use of calligraphy is a choice that many people do it for the writing of her pedigree charts or diagrams. Since it is a beautiful writing style, it is better selected each type of control.
If you choose a style you might want to consider a design for five generations. With the family crestDiagram is another nice touch. The five-generation has a perfect alignment of everything you want to add the chart. The design is with computers to ensure that all the names you want to add and the writing is perfect for the plot.
Another type of tree diagram of the family is one that starts with the grandparents and great work, until the present. This may have added pictures and a great gift idea for his relatives. Arranged in a fan chartThis chart is designed to provide the best solution for all the names.
A seven-generation graphics can be another great way to show the offspring of a family. If your children are grown up and well the parents have a card for every listing. The center of the diagram will be the key pair. Their children and spouses coming. Then follow the couple's grandchildren. Of the original pair at their left and right lists of their family, as mother, father andBrothers.
Another type of diagram that can hold about 500 names of your family is another fan-shaped graph with nine generations. The coat can be, even if they are placed. There are many kinds of writing that chosen to choose the style of the graphics can improve. The paper used can vary, but typically is acid-free and a map can parch his tone, if you want to appear older.
Although most examples of family trees to show the personRequest of the diagram, then head into the parents and grandparents are also more personalized designs that allow the addition of aunts, uncles, and cousins ??to be. Much depends on how hard you want to work, to find everything you want listed in the chart.
Since many people are divorced, widowed, they have accepted, and several other family circumstances that affect the family tree, they all get together can be tedious. But in the endResult will be worth it when you see how all the names together, like a report connected to the history of your family.
When choosing the type of the schema of the family tree to determine whether there is a generation of four or nine-generation is to be configured your way. Enter the name and other information that are specifically to fit the number of people, photo, logo and name of origin.
Since the size of a family tree diagram varyaccording to the number of names that can be a good idea to have custom framed to protect it as well. This will keep the pattern for many years to come and future generations have an advantage of their origin.
Found this article on Tea and Coffee Consumption and MRSA (methicillin-resistant Staphylococcus aureus) Nasal Carriage. http://www.annfammed.org/cgi/content/full/9/4/299 The study reported results, very unclearly, on a "sample included 5,555 individuals" and "we excluded individuals who were missing data on any variable. A total of 3,172 individuals were missing data." They found "secondary analysis of data from the 2003-2004 National Health and Nutrition Examination Survey to investigate the relationship between the consumption of coffee, hot tea, cold tea, and soft drinks, and MRSA nasal carriage ...Individuals who reported consuming coffee had about a one-half reduction in the risk of MRSA nasal carriage relative to individuals who drank no coffee (odds ratio = 0.47; 95% confidence interval, 0.24-0.93)." Nasal carriage does not imply infection but increases the risk for such, it is neither necessary nor sufficient. Food (or drink) for thought.
and "Coffee Helps Minimize Hepatitis C Treatment Side Effects" "Not only does coffee consumption slow liver disease progression and increase the chances of success while undergoing treatment for chronic hepatitis C infection, but drinking three or more cups a day also appears to reduce the incidence of hep C treatment side effects by more than 80 percent.
These findings, suggesting that coffee may greatly improve the tolerability of hepatitis C treatment, were presented at the 10th AIDS Impact conference, held from September 12 to 15 in Santa Fe, New Mexico, and reported by aidsmap." http://www.aidsmeds.com/articles/hiv_hcv_coffee_1667_21137.shtml This treatment is very poorly tolerated and most people forego Rx.
and "Advanced hepatitis C patients with chronic liver disease may benefit from drinking coffee during treatment, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. Patients who received peginterferon plus ribavirin treatment and who drank three or more cups of coffee per day were two times more likely to respond to treatment than non-drinkers." http://www.sciencedaily.com/releases/2011/06/110607105212.htm Original article not available to nonsuscribers
[unable to retrieve full-text content]The cell mobile phone has already progressed from a standard communication instrument to a total life style device integral to a persons messaging, details, and enjoyment wants. Extending the cell mobile phone to act as a wallet and ...
Infusing chemotherapy into the liver gives extra months of disease-free life in melanoma patientsPublic release date: 23-Sep-2011 [ | E-mail | Share ]
Contact: Emma Mason wordmason@mac.com ECCO-the European CanCer Organisation
Stockholm, Sweden: Melanoma of the eye (ocular or uveal melanoma) frequently spreads to the liver and, once this has happened, there is no effective treatment and patients die within an average of two to four months. Only about one in ten patients live for a year. Now, final results from a phase III study have demonstrated that a new treatment significantly extends the time patients can live without the disease progressing.
James Pingpank, associate professor of surgery at the University of Pittsburgh Cancer Institute (Pittsburgh, USA), will tell the 2011 European Multidisciplinary Cancer Congress [1] on Saturday that, by April 2011, the length of time that patients survived without the metastases spreading further in the liver (disease progression) was an average of 8.1 months for those receiving the new treatment compared to 1.6 months in the group of patients that had been randomised to receive the best alternative care.
The new treatment is called percutaneous hepatic perfusion (PHP) and is designed to saturate the liver with high doses of chemotherapy without affecting the rest of the body. The chemotherapy drug melphalan is infused directly into the liver via an intra-arterial catheter over a period of 30 minutes. Blood in the veins leading out of the liver is then captured and filtered through a specially designed, double-balloon catheter to extract the drug before the cleaned blood is returned to the body. This enables the drug to be delivered directly to the liver to target the melanoma metastases there, but in a minimally invasive manner. The patient is monitored in intensive care before being allowed home. Once the liver has recovered from the toxicity of the treatment, the procedure is repeated every four to eight weeks.
In a phase III, randomised trial that took place in nine US clinics, 93 patients were randomised to receive PHP or best alternative care between February 2006 and July 2009. Best alternative care (BAC) was decided by the patient's treatment team and could involve interleukin 2, ipilimumab, transcatheter arterial chemoembolisation (TACE), systemic chemotherapy or inclusion in a clinical trial.
As the study was not designed to show an overall survival benefit, and most of the patients had no other treatment options available to them, patients were allowed to cross over from the BAC arm of the study to the PHP arm once the benefits of PHP became apparent.
PHP patients had an overall progression-free survival time of 6.1 months versus 1.6 months in the BAC group. Overall survival at one year was 29% on PHP versus 26% on BAC. Due to the fact that 51% of patients crossed over from the BAC arm to the PHP arm, overall survival was not significantly different between the two groups: 11.4 months on PHP versus 9.9 months on BAC. However, those patients who did cross over seemed to do well despite being amongst the sickest, surviving for 9.2 months without the disease progressing in the liver, and 6.5 months without any overall progression of the disease.
Prof Pingpank will say: "This is the first phase III study of PHP in patients with liver-dominant metastatic melanoma and shows that PHP with melphalan significantly improves overall response rates and progression-free survival, providing a new treatment option for the disease. This report includes all data on patients who are more than one year on from inclusion in the trial and we now have all the final response rates. The only thing that may change over time is the examination of the possible long-term benefits, as all but one of the surviving patients were treated with PHP or crossed over to receive it."
For a disease that currently has few treatment options and no chance of a cure, Prof Pingpank says PHP offers patients extra months of, usually, good quality life. Although the adverse effects of PHP were more severe than BAC, they were short-lived. "Side effects were predominantly neutropenia [low white blood cell count] and thrombocytopenia [low platelet count]. The majority of patients were able to undergo multiple treatments in the PHP arm, as toxicity resolved, whereas the major toxicity in the control arm was liver failure and/or death on treatment from disease progression," he will say.
"This is the first treatment to show a clinical benefit in patients with liver metastases from ocular melanoma. Most patients retain 80% or more of their daily functional status, and return to full performance once therapy is completed. If subsequent recurrence is noted in the liver, retreatment is possible and effective. At this point, it appears that there are groups of patients surviving substantially longer than those control arm of the study, with good quality of liver and preservation of liver function."
PHP potentially could be used for other cancers that have spread to the liver. "We have demonstrated efficacy in a phase II setting for patients with metastatic neuroendocrine tumours [2], so the application of this technology is likely to expand to other tumour types," says Prof Pingpank. "In addition, we have previously demonstrated efficacy of high dose regional melphalan for patients with metastatic colorectal cancer, albeit through a different circuit."
The device that delivers and filters the melphalan has been approved in Europe for use in all malignant liver tumours, while approval is pending in the USA for melanoma only.
Prof Pingpank will conclude: "Certainly, with 50 percent of melanoma patients with metastatic liver disease dying of liver failure, we see this as a frontline therapy for patients with this disease. There is always controversy surrounding the application of regional therapy to patients with metastatic disease, especially when there is a high risk for metastases elsewhere in the body. However, at present, the dearth of options for patients with metastatic melanoma renders this a moot point, and this therapy will be an early choice for patients with liver-only disease."
Former president of ECCO and Director General of the Institut de Cancrologie Gustave Roussy (Paris, France), Professor Alexander Eggermont said: "The maturity of the data presented today better depicts the value as well as the limitations of percutaneous hepatic perfusion. One of the interesting points is that, in these relatively good patients, those that crossed over from the BAC arm of the study have good progression-free survival after a 'late' PHP that is about the same as when PHP is given upfront. In the absence of identified targets for targeted drugs in uveal melanoma, one might consider testing the role of ipilimumab following a PHP."
ESMO spokesman, Professor Ulrich Keilholz, of the Department of Hematology and Medical Oncology and Deputy Director at the Charit Comprehensive Cancer Center, Berlin, Germany, said: "The study by Pingpank is the first phase III trial in uveal melanoma and the first trial to show a benefit of regional treatment for liver metastases in this disease. Given the current lack of targeted drugs in this disease in contrast to the emerging treatments in cutaneous melanoma the clinically relevant benefit achieved with melphalan perfusion provides a new reference treatment for patients with hepatic metastases of uveal melanoma."
###
Abstract no: 9304. Saturday, 11.15 hrs (CEST), Melanoma and skin cancer session, Hall T1.
[1] The 2011 European Multidisciplinary Cancer Congress is the 16th congress of the European CanCer Organisation (ECCO), the 36th congress of the European Society for Medical Oncology (ESMO) and the 30th congress of European Society for Therapeutic Radiology and Oncology (ESTRO).
[2] See poster number 6621: "Percutaneous Hepatic Perfusion (PHF) with melphalan for patients with unresectable liver metastases of neuroendocrine tumours (MNET)". Poster on Monday in poster session on Gastrointestinal Malignancies - Noncolorectal Cancer.
[3] Funding for this trial was provided by Delcath Systems Inc, New York, and the US National Cancer Institute (NCI).
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Infusing chemotherapy into the liver gives extra months of disease-free life in melanoma patientsPublic release date: 23-Sep-2011 [ | E-mail | Share ]
Contact: Emma Mason wordmason@mac.com ECCO-the European CanCer Organisation
Stockholm, Sweden: Melanoma of the eye (ocular or uveal melanoma) frequently spreads to the liver and, once this has happened, there is no effective treatment and patients die within an average of two to four months. Only about one in ten patients live for a year. Now, final results from a phase III study have demonstrated that a new treatment significantly extends the time patients can live without the disease progressing.
James Pingpank, associate professor of surgery at the University of Pittsburgh Cancer Institute (Pittsburgh, USA), will tell the 2011 European Multidisciplinary Cancer Congress [1] on Saturday that, by April 2011, the length of time that patients survived without the metastases spreading further in the liver (disease progression) was an average of 8.1 months for those receiving the new treatment compared to 1.6 months in the group of patients that had been randomised to receive the best alternative care.
The new treatment is called percutaneous hepatic perfusion (PHP) and is designed to saturate the liver with high doses of chemotherapy without affecting the rest of the body. The chemotherapy drug melphalan is infused directly into the liver via an intra-arterial catheter over a period of 30 minutes. Blood in the veins leading out of the liver is then captured and filtered through a specially designed, double-balloon catheter to extract the drug before the cleaned blood is returned to the body. This enables the drug to be delivered directly to the liver to target the melanoma metastases there, but in a minimally invasive manner. The patient is monitored in intensive care before being allowed home. Once the liver has recovered from the toxicity of the treatment, the procedure is repeated every four to eight weeks.
In a phase III, randomised trial that took place in nine US clinics, 93 patients were randomised to receive PHP or best alternative care between February 2006 and July 2009. Best alternative care (BAC) was decided by the patient's treatment team and could involve interleukin 2, ipilimumab, transcatheter arterial chemoembolisation (TACE), systemic chemotherapy or inclusion in a clinical trial.
As the study was not designed to show an overall survival benefit, and most of the patients had no other treatment options available to them, patients were allowed to cross over from the BAC arm of the study to the PHP arm once the benefits of PHP became apparent.
PHP patients had an overall progression-free survival time of 6.1 months versus 1.6 months in the BAC group. Overall survival at one year was 29% on PHP versus 26% on BAC. Due to the fact that 51% of patients crossed over from the BAC arm to the PHP arm, overall survival was not significantly different between the two groups: 11.4 months on PHP versus 9.9 months on BAC. However, those patients who did cross over seemed to do well despite being amongst the sickest, surviving for 9.2 months without the disease progressing in the liver, and 6.5 months without any overall progression of the disease.
Prof Pingpank will say: "This is the first phase III study of PHP in patients with liver-dominant metastatic melanoma and shows that PHP with melphalan significantly improves overall response rates and progression-free survival, providing a new treatment option for the disease. This report includes all data on patients who are more than one year on from inclusion in the trial and we now have all the final response rates. The only thing that may change over time is the examination of the possible long-term benefits, as all but one of the surviving patients were treated with PHP or crossed over to receive it."
For a disease that currently has few treatment options and no chance of a cure, Prof Pingpank says PHP offers patients extra months of, usually, good quality life. Although the adverse effects of PHP were more severe than BAC, they were short-lived. "Side effects were predominantly neutropenia [low white blood cell count] and thrombocytopenia [low platelet count]. The majority of patients were able to undergo multiple treatments in the PHP arm, as toxicity resolved, whereas the major toxicity in the control arm was liver failure and/or death on treatment from disease progression," he will say.
"This is the first treatment to show a clinical benefit in patients with liver metastases from ocular melanoma. Most patients retain 80% or more of their daily functional status, and return to full performance once therapy is completed. If subsequent recurrence is noted in the liver, retreatment is possible and effective. At this point, it appears that there are groups of patients surviving substantially longer than those control arm of the study, with good quality of liver and preservation of liver function."
PHP potentially could be used for other cancers that have spread to the liver. "We have demonstrated efficacy in a phase II setting for patients with metastatic neuroendocrine tumours [2], so the application of this technology is likely to expand to other tumour types," says Prof Pingpank. "In addition, we have previously demonstrated efficacy of high dose regional melphalan for patients with metastatic colorectal cancer, albeit through a different circuit."
The device that delivers and filters the melphalan has been approved in Europe for use in all malignant liver tumours, while approval is pending in the USA for melanoma only.
Prof Pingpank will conclude: "Certainly, with 50 percent of melanoma patients with metastatic liver disease dying of liver failure, we see this as a frontline therapy for patients with this disease. There is always controversy surrounding the application of regional therapy to patients with metastatic disease, especially when there is a high risk for metastases elsewhere in the body. However, at present, the dearth of options for patients with metastatic melanoma renders this a moot point, and this therapy will be an early choice for patients with liver-only disease."
Former president of ECCO and Director General of the Institut de Cancrologie Gustave Roussy (Paris, France), Professor Alexander Eggermont said: "The maturity of the data presented today better depicts the value as well as the limitations of percutaneous hepatic perfusion. One of the interesting points is that, in these relatively good patients, those that crossed over from the BAC arm of the study have good progression-free survival after a 'late' PHP that is about the same as when PHP is given upfront. In the absence of identified targets for targeted drugs in uveal melanoma, one might consider testing the role of ipilimumab following a PHP."
ESMO spokesman, Professor Ulrich Keilholz, of the Department of Hematology and Medical Oncology and Deputy Director at the Charit Comprehensive Cancer Center, Berlin, Germany, said: "The study by Pingpank is the first phase III trial in uveal melanoma and the first trial to show a benefit of regional treatment for liver metastases in this disease. Given the current lack of targeted drugs in this disease in contrast to the emerging treatments in cutaneous melanoma the clinically relevant benefit achieved with melphalan perfusion provides a new reference treatment for patients with hepatic metastases of uveal melanoma."
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Abstract no: 9304. Saturday, 11.15 hrs (CEST), Melanoma and skin cancer session, Hall T1.
[1] The 2011 European Multidisciplinary Cancer Congress is the 16th congress of the European CanCer Organisation (ECCO), the 36th congress of the European Society for Medical Oncology (ESMO) and the 30th congress of European Society for Therapeutic Radiology and Oncology (ESTRO).
[2] See poster number 6621: "Percutaneous Hepatic Perfusion (PHF) with melphalan for patients with unresectable liver metastases of neuroendocrine tumours (MNET)". Poster on Monday in poster session on Gastrointestinal Malignancies - Noncolorectal Cancer.
[3] Funding for this trial was provided by Delcath Systems Inc, New York, and the US National Cancer Institute (NCI).
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If your are searching for a piece of fitness equipment to help furnish your home gym, then you should take an exercise bike into account. Next, ask yourself whether a recumbent or an upright model would suit you better. In the event that you have trouble getting around or keeping your balance, a recumbent model is right for you. For the utmost in results, though, upright bikes are more efficient. With an upright version, you lower body gets a complete workout and you don?t get the impacting movements connected with running, jogging, or walking.
If you bicycle at the right pace, you?ll gain significant cardiovascular benefits as well. Make certain to balance your pulse rate between the ranges you?ve set for your workout. To achieve this, gauge your maximum heart rate; next do your workout at a particular percentage of your heart rate.
Case in point, exercising at 60% to 70% of your maximum heart rate will supply you with aerobic ability and basic longevity. This is some data concerning an excellent exercise bike made by Life Fitness, the LifeCycle Club Series version.
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For monitoring your heart rate, this particular exercise cycle is equipped with wireless plus Lifepulse digital systems; furthermore, it has a chest strap. There is no need for an electrical connection as the cycle is self-powered. This makes it simple to relocate the bike to whatever place you want. Even another advanced facet is its ergonomic seat that has got a distinct groove which eases riding. The handlebars also have an ergonomic design, and include racing-style forearm support. The bike?s amenities entail an included reading rack, along with a sizeable double accessory tray.
Fitness Equipment: Additional Info on the Club Series Upright Exercise Cycle
While it is built for residential application, this is a high-quality item of fitness equipment that has many of the features found in Life Fitness? commercial models. Life Fitness merchandise is well-recognised and admired for their excellent functionality and strength, and also their compliance to accurate biomechanical principles. The business has supported this item with decades of pioneering design and formulation which produce a very efficient experience in riding. Life Fitness additionally has a generous on site lifetime service warranty on its frame, and also a one year service warranty on labour and three years on parts. The weight of this machine is 49kg, and the size is 122cm in length, 61cm in weight, and 137cm in height. It will support a maximum user weight of 180kg. Resistance comes from a self-contained alternator. The console display give feedback on speed, calories, time, distance, and also heart rate. Also displayed are effort, calories, level, watts, and METs.
Fitness Equipment: Concerning Life Fitness
Life Fitness started out more than forty years ago. Ever since, the organisation has kept a dedicated vision for its items and also for the clients who purchase them. Out from this vision materialised the globe?s foremost electronic item of fitness equipment, the celebrated LifeCycle.
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Managing your own virtual team can be difficult if you don?t know what you?re doing. The reason for that is, working with a virtual team is inherently different than working with a real live team. The kind of goals and objectives you want your team to achieve have to be re-enforced effectively, so that the deadlines are met and nothing is left for tomorrow. Remember that your ability to keep your businesses virtual team functioning at a high level will determine overall success.
First and foremost, if you want your new virtual team to work as a team and actually give results, you need to have a face to face meeting with them at least once. This way, the members of your team will be able to meet each other and start building a relationship while you can enforce the point that it doesn?t matter whether they are working remotely or not, there is still serious work to be done. Even though this may seem like an expensive decision to make, experts believe that it is worth it. Meeting face-to-face will allow you the liberty of revealing information you might not be comfortable sharing online and it also helps to build trust among the different members. You will need to balance your involvement, but it is in your best interest to help your virtual team become successful. That is why you should give them goals with milestones and deadlines, etc. Your team is capable of performing in excess of what they believe they can do, and it is your task to draw that out of them.
Finally, you need to have a vision so you can measure whether or not your team is generating results. Completing the work you assign them will be difficult unless you show them what your vision is. Your team needs to believe in the goals you have and they need to see the future as you do. And since it?s a virtual team, there?s a greater need to communicate your vision to them and help them understand what your main aim is and what you seek to achieve with your business. Your team will then be able to offer up their own ideas and targeted input to improve your vision. No one wants to work for the long term for a company that has no vision of the future, which is why they will be even more motivated to fulfill your ultimate goal if you offer them a powerful vision. It is true that a virtual team can be a tremendously valuable asset to any business. We strongly feel that communication is the key to success when working with a virtual team. The only way anything will be accomplished is through good communications, and that is why we stress this area so much.
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Basketball is now a person of the most widely used sports activities all the way through the complete planet. The big difference in between basketball and various of the other most popular sports activities is its fairly early origin. Basketball has a small historical past, and is a sport that was founded, in accordance to Basketball trivia, by Dr. James Naismith.
Dr. Naismith was a Canadian teacher of phys ed. In 1891 he was operating in Springfield, Massachusetts, with the YMCA. A Basketball quiz will exhibit that he invented the recreation seeking to find a thing that would keep the youthful adult males in shape in the course of the winter season. Numerous other video games have been not suited for enjoying indoors, or ended up not strenuous plenty of. So, Dr. Naismith attached peach baskets to a railing 10 feet huge and created a sport just where points have been scored by throwing a ball into the basket. That is how basketball London was born.
Basketball trivia exhibits a lot of fascinating modifications to the recreation about the years. Teams designed up of 5 people a aspect was a comparatively early adjust, taking spot in 1897. An important innovation was the backboard, launched in 1906, which opened up the recreation to shots that bounce in. Possibly the most valuable modify to the game alone arrived in the nineteen fifties. This was when basketballs (soccer balls had been applied initially) began to be produced in this sort of a way that they bounced evenly and uniformly. This is when dribbling became a element of the video game.
A basketball quiz will reveal the sport has gone by way of plenty of evolutions to achieve its ongoing qualified construction. The primary professional league had been built as early as 1898, whilst it would previous only a very few several years. Two leagues, the BAA (founded 1946) and the NBL, would merge in 1949 to construct the NBA, the national London basketball association. A new league, the American Basketball Association, started in 1967, but would finally merge with the NBA to leave the NBA in its up-to-date form.
Basketball has turned out to be these kinds of a trendy qualified activity to a massive degree considering the fact that of some of its most famed players. Before examples of these stars encompass people like Wilt Chamberlain and Kareem Abdul Jabar. Magic Johnson and Larry Bird could be said to stand for the future generation of star people. At present, players like Shaquille O?Neal, Kobe Bryant, and Lebron James retain the sport fascinating for followers. The most well known basketball player of all time is devoid of a doubt Michael Jordan, and he also has to be provided a great offer of credit for the improving popularity of the sport.
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For the latest news about NASA's UARS spacecraft fall, visit: Falling NASA Satellite: Complete Coverage of UARS Spacecraft's Fiery Demise.
A decommissioned NASA satellite is expected to plummet to Earth today (Sept. 23), and agency officials are monitoring the dead spacecraft closely to try to narrow down when and where the debris will fall.
According to NASA, the Upper Atmosphere Research Satellite, or UARS, will make its fiery descent through the atmosphere some time this afternoon or early evening (Eastern Daylight Time), but while it is still too soon to tell where pieces of the defunct satellite will land, scientists have been able to rule out North America from the potential impact zone.?
"Re-entry is possible sometime during the afternoon or early evening of Sept. 23, Eastern Daylight Time. The satellite will not be passing over North America during that time period," NASA officials said in a statement late Thursday. "It is still too early to predict the time and location of re-entry with any more certainty, but predictions will become more refined in the next 24 hours." [Photos of NASA's Huge Falling Satellite UARS]
The bus-size, 6.5-ton UARS spacecraft is one of the largest NASA satellites to plunge back to Earth uncontrolled in more than 30 years.
"The most massive NASA satellite to re-enter uncontrolled since Skylab was the Pegasus 2 satellite in November 1979," Nick Johnson, chief scientist of NASA's Orbital Debris Program Office at the Johnson Space Center in Houston, told SPACE.com in an e-mail last week. "It had a mass of 10.5 metric tons, almost twice that of UARS."?
Skylab, the first American space station, fell to Earth in 1979, and debris from the outpost plunged into the Indian Ocean and onto parts of Australia. The Pegasus 2 satellite was launched in 1965 to study micrometeoroids in low-Earth orbit. The satellite remained in orbit for 14 years before splashing down into the mid-Atlantic Ocean on Nov. 3, 1979.[6 Biggest Spacecraft to Fall Uncontrolled From Space]
Despite the fact that UARS will fall to Earth uncontrolled, NASA officials have stated that the chance of debris landing in populated regions of the planet is extremely remote.
"There's always a concern," said Mark Matney, a scientist at the Orbital Debris Program Office. "But, populated areas are a small fraction of the Earth's surface. Much of the Earth's surface has either no people or very few people. We believe that the risk is very modest."
Scientists at the Orbital Debris Program Office at the agency's Johnson Space Center in Houston calculated the odds that anyone anywhere in the world will be hit by UARS debris at 1-in-3,200. But, the chance that you personally will get hit is much smaller, somewhere on the order of 1-in-several trillion, NASA officials said. [How You Can Track the Falling Satellite]
Agency officials have estimated that roughly 26 large pieces of the satellite will survive the intense journey through Earth's atmosphere. Approximately 1,170 pounds (532 kilograms) of material is expected to actually reach the ground, but even though the spacecraft is expected to re-enter over a 500-mile (804-kilometer) path, these pieces will likely fall over water or uninhabited areas of the planet, Matney said. [Where Could UARS Satellite Debris Fall?]
The $750 million climate satellite measures 35 feet (10.7 meters) long and 15 feet (4.5 m) wide. It was launched in 1991 aboard the space shuttle Discovery, and studied the ozone layer and chemical makeup of Earth's upper atmosphere before it was decommissioned in December 2005.
Originally, NASA anticipated that the UARS satellite would fall to Earth sometime between late September and early October, but heightened solar activity last week increased the spacecraft's drag, pulling it down to Earth sooner than expected. You can track the UARS satellite fall using several skywatching tools, including the?Satellite AR Android app created by the company Analytical Graphics Inc.
Editor's note: If you snap a photo or observe the re-entry of NASA's UARS satellite and want to share it with?SPACE.com?for a story or gallery, contact managing editor Tariq Malik at:?tmalik@space.com.
You can follow SPACE.com staff writer Denise Chow on Twitter @denisechow. Follow SPACE.com for the latest in space science and exploration news on Twitter @Spacedotcom and on Facebook.
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